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Effects of Selective Serotonin Reuptake Inhibitors on Depression-Like Behavior in a Laser-Induced Shock Wave Model
- Source :
- Frontiers in Neurology, Vol 12 (2021), Frontiers in Neurology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Primary blast injury can result in depression-like behavior in the long-term. However, the effects of the selective serotonin reuptake inhibitor (SSRI) on the depression induced by mild blast traumatic brain injury (bTBI) in the long-term remain unclear. We generated a mouse model of mild bTBI using laser-induced shock wave (LISW) and administered an SSRI to mice by oral gavage for 14 days after LISW exposure. This study aimed to investigate the mechanisms of SSRI-mediated alleviation of depression-like behavior induced by mild bTBI. Animals were divided into three groups: sham, LISW-Vehicle, and LISW-SSRI. LISW was applied to the head of anesthetized mice at 0.5 J/cm2. Twenty-eight days after the LISW, mice in the LISW-SSRI group exhibited reduced depression-like behavior, a significant increase in the number of cells co-stained for 5-bromo-2'-deoxyuridine (Brd-U) and doublecortin (DCX) in the dentate gyrus (DG) as well as increased brain-derived neurotrophic factor (BDNF) and serotonin levels in the hippocampus compared to the sham and LISW-Vehicle groups. Additionally, levels of phosphorylated cAMP response element binding protein (pCREB) in the DG were significantly decreased in the LISW-Vehicle group compared to that in the sham group. Importantly, pCREB levels were not significantly different between LISW-SSRI and sham groups suggesting that SSRI treatment may limit the downregulation of pCREB induced by mild bTBI. In conclusion, recovery from depression-like behavior after mild bTBI may be mediated by hippocampal neurogenesis induced by increased BDNF and serotonin levels as well as the inhibition of pCREB downregulation in the hippocampus.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Serotonin reuptake inhibitor
Hippocampus
Hippocampal formation
lcsh:RC346-429
03 medical and health sciences
0302 clinical medicine
phosphorylated cAMP response element binding protein
Internal medicine
medicine
lcsh:Neurology. Diseases of the nervous system
Original Research
laser-induced shock wave
Brain-derived neurotrophic factor
selective serotonin reuptake inhibitor
biology
business.industry
Dentate gyrus
brain-derived neurotrophic factor
Neurogenesis
Doublecortin
neurogenesis
030104 developmental biology
Endocrinology
Neurology
mild blast traumatic brain injury
depression
biology.protein
Neurology (clinical)
Serotonin
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....ff97a7d9b7ce5f32998f8758a985f523
- Full Text :
- https://doi.org/10.3389/fneur.2021.602038