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A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients
- Source :
- Polish Journal of Pathology, Vol 67, Iss 3, Pp 235-243 (2016)
- Publication Year :
- 2016
- Publisher :
- Termedia Publishing House, 2016.
-
Abstract
- The aim of the study was to assess the incidence of CD5-positive diffuse large B-cell lymphoma (DLBCL) in the Polish population and to describe its morphologic and clinical characteristics. The study included 36 patients with CD5-positive DLBCL, diagnosed and treated in the Maria Sklodowska-Curie Institute and Oncology Centre, Warsaw, Poland and the Medical University of Warsaw, Poland in the years 2002-2013. The control group consisted of 28 patients with CD5-negative DLBCL. CD5-positive DLBCL accounted for 6.26% of all DLBCL cases diagnosed in the Maria Sklodowska-Curie Institute and Oncology Centre in the years 2008-2012. The incidence is comparable to other European countries, lower than noted in Japan and higher than in the US. Patients with CD5-positive DLBCL, in comparison to the CD5-negative group, were characterized by: (1) older age (≥ 60 vs. younger) and worse general status (ECOG ≥ 2 vs. < 2), (2) lower frequency of complete remission (CR), (3) higher expression of unfavorable prognostic factors (BCL2, FOXP1, CD44) and MMP-9, and (4) lower expression of favorable prognostic factors (CD30, cyclin D1, cyclin D3) and TIMP-2.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
CD30
lcsh:Medicine
Polish population
CD5-positive DLBCL
030204 cardiovascular system & hematology
CD5 Antigens
NHL
Immunophenotyping
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
immune system diseases
Internal medicine
hemic and lymphatic diseases
medicine
Humans
neoplasms
Aged
Aged, 80 and over
business.industry
Incidence
Incidence (epidemiology)
lcsh:R
Complete remission
prognostic factors
General Medicine
Middle Aged
CD5 Positive
medicine.disease
Immunohistochemistry
Lymphoma
030220 oncology & carcinogenesis
Female
Lymphoma, Large B-Cell, Diffuse
Poland
business
Diffuse large B-cell lymphoma
Subjects
Details
- Language :
- English
- ISSN :
- 20849869 and 12339687
- Volume :
- 67
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Polish Journal of Pathology
- Accession number :
- edsair.doi.dedup.....ff98e956e73865aa0d7d764a714a1fa1