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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
- Source :
- Nature Genetics, 47(12), 1449-1456. Nature Publishing Group, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bonnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Moller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Rueschendorf, F, Bauerfeind, A, Lee-Kirsch, M A, Arnold, A, Homuth, G, Schmidt, C O, Mangold, E, Cichon, S, Keil, T, Rodriguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Foelster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, L L, Grarup, N, de Jongste, J C, Rivadeneira, F, Hofman, A, Jaddoe, V W V, Pasmans, S G M A, Elbert, N J, Uitterlinden, A G, Marks, G B, Thompson, P J, Matheson, M C, Robertson, C F, Ried, J S, Li, J, Zuo, X B, Zheng, X D, Yin, X Y, Sun, L D, McAleer, M A, O'Regan, G M, Fahy, C M R, Campbell, L E, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, D S, Feenstra, B, Geller, F, Hottenga, J J, Middeldorp, C M, Hysi, P, Bataille, V, Spector, T, Tiesler, C M T, Thiering, E, Pahukasahasram, B, Yang, J J, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, C L, Myhre, R, Nystad, W, Custovic, A, Weiss, S T, Meyers, D A, Soederhaell, C, Melen, E, Ober, C, Raby, B A, Simpson, A, Jacobsson, B, Holloway, J W, Bisgaard, H, Sunyer, J, Probst-Hensch, N M, Williams, L K, Godfrey, K M, Wang, C A, Boomsma, D I, Melbye, M, Koppelman, G H, Jarvis, D, McLean, W H I, Irvine, A D, Zhang, X J, Hakonarson, H, Gieger, C, Burchard, E G, Martin, N G, Duijts, L, Linneberg, A, Jarvelin, M, Noethen, M M, Lau, S, Huebner, N, Lee, Y, Tamari, M, Hinds, D A, Glass, D, Brown, S J, Heinrich, J, Evans, D M & Weidinger, S 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449-1456 . https://doi.org/10.1038/ng.3424, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Relton, C L, Duijts, L, Lee, Y-A, Evans, D M 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449-1456 . https://doi.org/10.1038/ng.3424, Nature Genetics, 47(12), 1449-1458. Nature Publishing Group, Recercat. Dipósit de la Recerca de Catalunya, instname, Nature genetics, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Rüschendorf, F, Bauerfeind, A, Lee-Kirsch, M A, Arnold, A, Homuth, G, Schmidt, C O, Mangold, E, Cichon, S, Keil, T, Rodríguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Fölster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, L L, Grarup, N, de Jongste, J C, Rivadeneira, F, Hofman, A, Jaddoe, V W V, Pasmans, S G M A, Elbert, N J, Uitterlinden, A G, Marks, G B, Thompson, P J, Matheson, M C, Robertson, C F, (AAGC), A A G C, Ried, J S, Li, J, Zuo, X B, Zheng, X D, Yin, X Y, Sun, L D, McAleer, M A, O'Regan, G M, Fahy, C M R, Campbell, L E, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, D S, Feenstra, B, Geller, F, Hottenga, J J, Middeldorp, C M, Hysi, P, Bataille, V, Spector, T, Tiesler, C M T, Thiering, E, Pahukasahasram, B, Yang, J J, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, C L, Myhre, R, Nystad, W, Custovic, A, Weiss, S T, Meyers, D A, Söderhäll, C, Melén, E, Ober, C, Raby, B A, Simpson, A, Jacobsson, B, Holloway, J W, Bisgaard, H, Sunyer, J, Probst-Hensch, N M, Williams, L K, Godfrey, K M, Wang, C A, Boomsma, D I, Melbye, M, Koppelman, G H, Jarvis, D, McLean, W H I, Irvine, A D, Zhang, X J, Hakonarson, H, Gieger, C, Burchard, E G, Martin, N G, Duijts, L, Linneberg, A, Jarvelin, M-R, Nöthen, M M, Lau, S, Hübner, N, Lee, Y-A, Tamari, M, Hinds, D A, Glass, D, Brown, S J, Heinrich, J, Evans, D M, Weidinger, S, Genetics, EA & Consortium, L E E 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449—1456 . https://doi.org/10.1038/ng.3424, Nature Genetics, 47(12), 1449-+. Nature Publishing Group
- Publication Year :
- 2015
-
Abstract
- Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis. This research was specifically funded by an MRC Population Health Scientist Fellowship awarded to Dr L Paternoster (MR/J012165/1). D.M.E. is supported by an Australian Research Council Future Fellowship (FT130101709) and a Medical Research Council program grant (MC_UU_12013/4)
- Subjects :
- Netherlands Twin Register (NTR)
Candidate gene
T-Lymphocytes
Genome-wide association study
VARIANTS
Genome-wide association studies
EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium
Risk Factors
Ethnicity
health care economics and organizations
Genetics & Heredity
Genetics
PSORIASIS
11 Medical And Health Sciences
Atopic dermatitis
3. Good health
Life Sciences & Biomedicine
Dermatitis atòpica
Genetic Markers
medicine.medical_specialty
SUSCEPTIBILITY LOCI
education
Biology
Australian Asthma Genetics Consortium (AAGC)
Polymorphism, Single Nucleotide
Article
Dermatitis, Atopic
GENETIC ARCHITECTURE
SDG 3 - Good Health and Well-being
Molecular genetics
medicine
Humans
FILAGGRIN
Genetic Predisposition to Disease
JAPANESE POPULATION
Genomes
METAANALYSIS
Genetic association
Science & Technology
Case-control study
Grups ètnics
INTERLEUKIN-7 RECEPTOR
06 Biological Sciences
medicine.disease
Immunity, Innate
Genetic architecture
Genetic Loci
Genetic marker
Case-Control Studies
Immunology
ASTHMA
Genètica
Developmental Biology
Genome-Wide Association Study
INFLAMMATORY-BOWEL-DISEASE
Subjects
Details
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, 47(12), 1449-1456. Nature Publishing Group, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bonnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Moller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Rueschendorf, F, Bauerfeind, A, Lee-Kirsch, M A, Arnold, A, Homuth, G, Schmidt, C O, Mangold, E, Cichon, S, Keil, T, Rodriguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Foelster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, L L, Grarup, N, de Jongste, J C, Rivadeneira, F, Hofman, A, Jaddoe, V W V, Pasmans, S G M A, Elbert, N J, Uitterlinden, A G, Marks, G B, Thompson, P J, Matheson, M C, Robertson, C F, Ried, J S, Li, J, Zuo, X B, Zheng, X D, Yin, X Y, Sun, L D, McAleer, M A, O'Regan, G M, Fahy, C M R, Campbell, L E, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, D S, Feenstra, B, Geller, F, Hottenga, J J, Middeldorp, C M, Hysi, P, Bataille, V, Spector, T, Tiesler, C M T, Thiering, E, Pahukasahasram, B, Yang, J J, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, C L, Myhre, R, Nystad, W, Custovic, A, Weiss, S T, Meyers, D A, Soederhaell, C, Melen, E, Ober, C, Raby, B A, Simpson, A, Jacobsson, B, Holloway, J W, Bisgaard, H, Sunyer, J, Probst-Hensch, N M, Williams, L K, Godfrey, K M, Wang, C A, Boomsma, D I, Melbye, M, Koppelman, G H, Jarvis, D, McLean, W H I, Irvine, A D, Zhang, X J, Hakonarson, H, Gieger, C, Burchard, E G, Martin, N G, Duijts, L, Linneberg, A, Jarvelin, M, Noethen, M M, Lau, S, Huebner, N, Lee, Y, Tamari, M, Hinds, D A, Glass, D, Brown, S J, Heinrich, J, Evans, D M & Weidinger, S 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449-1456 . https://doi.org/10.1038/ng.3424, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Relton, C L, Duijts, L, Lee, Y-A, Evans, D M 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449-1456 . https://doi.org/10.1038/ng.3424, Nature Genetics, 47(12), 1449-1458. Nature Publishing Group, Recercat. Dipósit de la Recerca de Catalunya, instname, Nature genetics, Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, D P, Curtin, J A, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, A C, Thyssen, J P, den Dekker, H T, Ferreira, M A, Altmaier, E, Sleiman, P M A, Xiao, F L, Gonzalez, J R, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, M M, Venturini, C, Pennell, C E, Barton, S J, Levin, A M, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, G A, Bacelis, J, Bunyavanich, S, Myers, R A, Matanovic, A, Kumar, A, Tung, J Y, Hirota, T, Kubo, M, McArdle, W L, Henderson, A J, Kemp, J P, Zheng, J, Smith, G D, Rüschendorf, F, Bauerfeind, A, Lee-Kirsch, M A, Arnold, A, Homuth, G, Schmidt, C O, Mangold, E, Cichon, S, Keil, T, Rodríguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Fölster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, L L, Grarup, N, de Jongste, J C, Rivadeneira, F, Hofman, A, Jaddoe, V W V, Pasmans, S G M A, Elbert, N J, Uitterlinden, A G, Marks, G B, Thompson, P J, Matheson, M C, Robertson, C F, (AAGC), A A G C, Ried, J S, Li, J, Zuo, X B, Zheng, X D, Yin, X Y, Sun, L D, McAleer, M A, O'Regan, G M, Fahy, C M R, Campbell, L E, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, D S, Feenstra, B, Geller, F, Hottenga, J J, Middeldorp, C M, Hysi, P, Bataille, V, Spector, T, Tiesler, C M T, Thiering, E, Pahukasahasram, B, Yang, J J, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, C L, Myhre, R, Nystad, W, Custovic, A, Weiss, S T, Meyers, D A, Söderhäll, C, Melén, E, Ober, C, Raby, B A, Simpson, A, Jacobsson, B, Holloway, J W, Bisgaard, H, Sunyer, J, Probst-Hensch, N M, Williams, L K, Godfrey, K M, Wang, C A, Boomsma, D I, Melbye, M, Koppelman, G H, Jarvis, D, McLean, W H I, Irvine, A D, Zhang, X J, Hakonarson, H, Gieger, C, Burchard, E G, Martin, N G, Duijts, L, Linneberg, A, Jarvelin, M-R, Nöthen, M M, Lau, S, Hübner, N, Lee, Y-A, Tamari, M, Hinds, D A, Glass, D, Brown, S J, Heinrich, J, Evans, D M, Weidinger, S, Genetics, EA & Consortium, L E E 2015, ' Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis ', Nature Genetics, vol. 47, no. 12, pp. 1449—1456 . https://doi.org/10.1038/ng.3424, Nature Genetics, 47(12), 1449-+. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....ffaf379dca827e2cb3391d8b5a2c1ae9
- Full Text :
- https://doi.org/10.1038/ng.3424