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A Longitudinal Examination of Plasma Neurofilament Light and Total Tau for the Clinical Detection and Monitoring of Alzheimer’s Disease
- Source :
- Neurobiol Aging
- Publication Year :
- 2020
-
Abstract
- We examined baseline and longitudinal associations between plasma neurofilament light (NfL) and total tau (t-tau), and the clinical presentation of Alzheimer's disease (AD). A total of 579 participants (238, normal cognition [NC]; 185, mild cognitive impairment [MCI]; 156, AD dementia) had baseline blood draws; 82% had follow-up evaluations. Plasma samples were analyzed for NfL and t-tau using Simoa technology. Baseline plasma NfL was higher in AD dementia than MCI (standardized mean difference = 0.55, 95% CI: 0.37–0.73) and NC (standardized mean difference = 0.68, 95% CI: 0.49–0.88), corresponded to Clinical Dementia Rating scores (OR = 1.94, 95% CI: 1.35–2.79]), and correlated with all neuropsychological tests (r's = 0.13–0.42). Longitudinally, NfL did not predict diagnostic conversion but predicted decline on 3/10 neuropsychological tests. Baseline plasma t-tau was higher in AD dementia than NC with a small effect (standardized mean difference = 0.33, 95% CI: 0.10–0.57) but not MCI. t-tau did not statistically significant predict any longitudinal outcomes. Plasma NfL may be useful for the detection of AD dementia and monitoring of disease progression. In contrast, there was minimal evidence in support of plasma t-tau.
- Subjects :
- 0301 basic medicine
Male
Aging
medicine.medical_specialty
Clinical Dementia Rating
Neurofilament light
Total tau
tau Proteins
Disease
Neuropsychological Tests
Article
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Neurofilament Proteins
Predictive Value of Tests
Internal medicine
mental disorders
medicine
Dementia
Humans
Cognitive Dysfunction
Longitudinal Studies
Aged
Monitoring, Physiologic
Aged, 80 and over
business.industry
General Neuroscience
Disease progression
Neuropsychology
medicine.disease
030104 developmental biology
Disease Progression
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Developmental Biology
Blood drawing
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Neurobiol Aging
- Accession number :
- edsair.doi.dedup.....ffbcf52e3223e8a82a7acc7f1878f118