Open-access electronic diary for motor fluctuation and dyskinesia evaluation in aprkinson disease: comparison with paper diary

Fil: Terroba Chambi, Cinthia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Terroba Chambi, Cinthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Terroba Chambi, Cinthia. Fleni. Departamento de Neurociencias; Argentina Fil: Bruno, Veronica. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Bruno, Veronica. Fleni. Departamento de Neurociencias; Argentina Fil: Bruno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Medina Escobar, Alex. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Medina Escobar, Alex. Fleni. Departamento de Neurociencias; Argentina Fil: Nanni, Federico. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Nanni, Federico. Fleni. Departamento de Neurociencias; Argentina Fil: Cerquetti, Daniel. Fleni. Departamento de Neurociencias; Argentina Fil: Cerquetti, Daniel. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Rossi, Malco Damián. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Rossi, Malco Damián. Fleni. Departamento de Neurociencias; Argentina Fil: Merello, Marcelo. Fleni. Departamento de Neurociencias; Argentina Fil: Merello, Marcelo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Merello, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: Objective - To determine the utility of an electronic diary for registering motor fluctuations and dyskinesia in Parkinson disease (PD). Methods - Free, open-access touch screen software suitable for Android 4.4 or higher, with medication alarms, adjustable intervals, and medication dose settings was developed to evaluate ON-OFF periods and dyskinesia. Prospective evaluation included a first phase conducted to make adjustments concerning motor limitations when using the tablet, as well as for proper motor complication identification, and a second phase of 3 days of use at home with a prior diary training session comparing a modified paper version of Core Assessment Program for Surgical Interventional Therapies in PD and the electronic diary. Results - All patients correctly identified ON-OFF periods and dyskinesia. Rater/patient matching ON-OFF fluctuations ranged between 94% and 100% for evaluations of different motor states. Dyskinesia matching percentage was 100% for patients with dyskinesia interfering with activities of daily living and 88% for those who reported no-interference. No significant differences between paper and electronic diaries were identified when reporting ON-OFF motor states or in the number of errors when filling the diaries. Conclusions - This electronic motor diary proved to be reliable for ON-OFF state and dyskinesia identification and classification. However, no advantage to paper diary has been observed in terms of number of erroneous entries. Based on these results, to improve home motor fluctuations, detection efforts should be directed toward the development of automatic wearable devices rather than digital versions of current available ON-OFF diaries.