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Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families
- Source :
- Mitochondrial DNA. :1-10
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- Previous work suggests that mitochondrial DNA (mtDNA) derived from the maternal genome has a close affinity with type 2 diabetes. This would support a familial pattern for type 2 diabetes. Thereby, we analyzed complete mtDNA genomes from two families, A and B, from Southwest China that demonstrated maternally inherited type 2 diabetes. Our data support that mtDNA lineages from families A and B belong to haplogroups A4 and D4h1, respectively. This suggests that maternally inherited type 2 diabetes with similar penetrances can arise in Chinese individuals with strikingly different maternal genetic backgrounds. Two private coding region mutations (G13759A in MT-ND5 and G15930A in tRNA-Thr) were identified in family B. Further evolutionary and phylogenetic analyses suggest that both these mutations have multiple origins and are unlikely to be disease causing.
- Subjects :
- Adult
Male
Mitochondrial DNA
Inheritance Patterns
Penetrance
Type 2 diabetes
Disease
Biology
DNA, Mitochondrial
Genome
Haplogroup
Evolution, Molecular
Open Reading Frames
Asian People
Genetics
medicine
Humans
Coding region
Family
Molecular Biology
Phylogeny
Phylogenetic tree
medicine.disease
Pedigree
Diabetes Mellitus, Type 2
Genome, Mitochondrial
Mutation
Female
Subjects
Details
- ISSN :
- 19401744 and 19401736
- Database :
- OpenAIRE
- Journal :
- Mitochondrial DNA
- Accession number :
- edsair.doi.dedup.....ffdc9ed0292c141af1c02634cd964394