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Minocycline HCl Microspheres Reduce Red-Complex Bacteria in Periodontal Disease Therapy
- Source :
- Journal of Periodontology. 78:1568-1579
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background: The objective of this trial was to measure the antimicrobial effects of a minocycline HCl microsphere (MM) local drug-delivery system when used as an adjunct to scaling and root planing (SRP). DNA probe analysis for 40 bacteria was used to evaluate the oral bacteria of 127 subjects with moderate to advanced chronic periodontitis. Methods: Subjects were randomly assigned to either SRP alone (N = 65) or MM + SRP (N = 62). The primary endpoints of this study were changes in numbers and proportions of the red-complex bacteria (RCB) and the sum of Porphyromonas gingivalis, Tannerella forsythia (formally T. forsythensis), and Treponema denticola relative to 40 oral bacteria at each test site from baseline to day 30. Numbers of RCB from the five test sites were averaged to provide a value for each subject. Results: MM + SRP reduced the proportion of RCB by 6.49% and the numbers by 9.4 · 10 5 . The reduction in RCB proportions and numbers by SRP alone (5.03% and 5.1 · 10 5 , respectively) was significantly less. In addition, MM + SRP reduced probing depth by 1.38 mm (compared to 1.01 mm by SRP alone), bleeding on probing was reduced by 25.2% (compared to 13.8% by SRP alone), and a clinical attachment level gain of 1.16 mm (compared to 0.80 mm by SRP alone) was achieved. Conclusion: These observations support the hypothesis that RCBs are responsible for periodontal disease and that local antimicrobial therapy using MM + SRP effectively reduces numbers of RCBs and their proportions to a greater extent than SRP alone. J Periodontol 2007;78:1568-1579.
- Subjects :
- Male
medicine.medical_specialty
Administration, Topical
Bleeding on probing
Colony Count, Microbial
Dental Plaque
Minocycline
environment and public health
Gastroenterology
Root Planing
Microbiology
Drug Delivery Systems
Scaling and root planing
Internal medicine
Periodontal Attachment Loss
medicine
Bacteroides
Humans
Periodontal Pocket
Tannerella forsythia
Single-Blind Method
Periodontitis
Antibacterial agent
Bacteria
biology
business.industry
Treponema denticola
Middle Aged
biology.organism_classification
medicine.disease
Red complex
Chronic periodontitis
Microspheres
Anti-Bacterial Agents
Treatment Outcome
Dental Scaling
Periodontics
Female
medicine.symptom
Gingival Hemorrhage
business
Porphyromonas gingivalis
Subjects
Details
- ISSN :
- 19433670 and 00223492
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of Periodontology
- Accession number :
- edsair.doi.dedup.....ffef2f3d4ed11e2acca3a19e1979156b