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Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2
- Source :
- ACS Med Chem Lett
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- [Image: see text] Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.
- Subjects :
- biology
010405 organic chemistry
medicine.drug_class
business.industry
Organic Chemistry
Antibiotics
Aztreonam
biochemical phenomena, metabolism, and nutrition
Prodrug
Pharmacology
bacterial infections and mycoses
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
Bioavailability
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
chemistry
Drug Discovery
polycyclic compounds
medicine
bacteria
business
Bacteria
Subjects
Details
- ISSN :
- 19485875
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- ACS Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....fffbd7d2d5a5ccae1b375ffbf4fa6355