CART cell therapy for prostate cancer: status and promise

Haiyuan Yu,1,* Jun Pan,1,* Zhicheng Guo,1 Chunhua Yang,1,2 Lijun Mao1,2 1Department of Urinary Surgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China; 2Jiangsu Key Laboratory of Biological Cancer Therapy, Department of Clinic Institute, Xuzhou Medical University, Xuzhou 221002, China *These authors contributed equally to this work Abstract: In recent years, the, chimeric antigen receptor T (CAR-T) cell therapy as an adoptive immunotherapy has received great attention and made great breakthroughs. CAR-T cells show great specificity, targeting, and less major histocompatibility complex restriction in tumor immunotherapy, significantly different from traditional T cells. In spite of the progress of CART-T technology in the treatment of lymphoma, leukemia, and other blood system tumor, there are still many difficulties in the treatment of solid tumors by CAR-T technology. In this review, we will make a brief summary of the present situation of CAR-T cells in the treatment of prostate cancer, and discuss the promise of the application of this technology to prostate cancer therapy. Keywords: prostate cancer, CAR-T cells, adoptive immunotherapy, review