An Update in Our Understanding of the Relationships Between Gene Polymorphisms and Chemotherapy-Induced Nausea and Vomiting

Yilan Jin,* Xiaorong Li,* Caihong Jiang,* Jun Zhao, Guang Liu, Hui Li, Gaowa Jin, Quanfu Li Department of Medical Oncology, Ordos Central Hospital, Ordos, 017000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Quanfu Li; Gaowa JinDepartment of Medical Oncology, Ordos Central Hospital, 23th Yinjihuoluo Western Road, Ordos, 017000, People’s Republic of ChinaTel +86 0477-8363279Fax +86 0477-8363158Email li_qfedu@163.com; jingw145@126.comAbstract: The occurrence and severity of chemotherapy-induced nausea and vomiting (CINV) are influenced by many factors; this includes therapeutic factors, such as the dose, administration mode, and chemotherapeutic agent emetogenicity, as well as patient-related risk factors, such as the gender, age, alcohol consumption history, and anxiety level. However, these factors cannot fully explain the individual CINV differences. In recent years, the correlation between gene polymorphism and CINV has been a hot research topic; the present paper reviews current research on CINV-related gene polymorphisms, and the results indicate that the use of gene polymorphism for the optimization of CINV efficacy is of important clinical significance.Keywords: chemotherapy-induced nausea and vomiting, gene polymorphisms, prevention and treatment, antiemetic