Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiaton and that the antigen-presenting cell (APC) is an important traget for this DNA damage. Chemicals/CAS: DNA, 9007-49-2