Back to Search Start Over

Overcome Cancer Cell Drug Resistance Using Natural Products

Authors :
Wang, Pu
Yang, Hua Li
Yang, Ying Juan
Wang, Lan
Lee, Shao Chin
Source :
Evidence-Based Complementary and Alternative Medicine.
Publication Year :
2015
Publisher :
Hindawi Publishing Corporation, 2015.

Abstract

Chemotherapy is one of the major treatment methods for cancer. However, failure in chemotherapy is not uncommon, mainly due to dose-limiting toxicity associated with drug resistance. Management of drug resistance is important towards successful chemotherapy. There are many reports in the Chinese literature that natural products can overcome cancer cell drug resistance, which deserve sharing with scientific and industrial communities. We summarized the reports into four categories: (1) in vitro studies using cell line models; (2) serum pharmacology; (3) in vivo studies using animal models; and (4) clinical studies. Fourteen single compounds were reported to have antidrug resistance activity for the first time. In vitro, compounds were able to overcome drug resistance at nontoxic or subtoxic concentrations, in a dose-dependent manner, by inhibiting drug transporters, cell detoxification capacity, or cell apoptosis sensitivity. Studies in vivo showed that single compounds, herbal extract, and formulas had potent antidrug resistance activities. Importantly, many single compounds, herbal extracts, and formulas have been used clinically to treat various diseases including cancer. The review provides comprehensive data on use of natural compounds to overcome cancer cell drug resistance in China, which may facilitate the therapeutic development of natural products for clinical management of cancer drug resistance.

Subjects

Subjects :
Article Subject

Details

Language :
English
ISSN :
1741427X
Database :
OpenAIRE
Journal :
Evidence-Based Complementary and Alternative Medicine
Accession number :
edsair.hindawi.publ..30db5cc4f7574b891131087b3e758b68
Full Text :
https://doi.org/10.1155/2015/767136