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Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis

Authors :
Margaritopoulos, George A.
Tsitoura, Eliza
Tzanakis, Nikos
Spandidos, Demetrios A.
Siafakas, Nikos M.
Sourvinos, George
Antoniou, Katerina M.
Source :
BioMed Research International.
Publication Year :
2013
Publisher :
Hindawi Publishing Corporation, 2013.

Abstract

Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis.

Subjects

Subjects :
Article Subject

Details

Language :
English
ISSN :
23146133
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.hindawi.publ..3fa0bf032fedd3fe45452341623ef338
Full Text :
https://doi.org/10.1155/2013/420497