Evaluation of olfactory impairment using a simple test kit 'The Odor Stick Identification test for the Japanese' (OSIT-J) in neurodegenerative diseases

Purpose: Olfactory deficit has been studied in aging, amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD). Parkinson's disease (PD), dementia with Lewy bodies (DLB) and idiopathic REM-sleep behavior disorder (iRBD). Our aim was to investigate the usefulness of a simple test kit “The Odor Stick Identification test for the Japanese ”(OSIT-J) in clinical practice. Methods: A total of 240 patients were enrolled in this study, including 44 cognitively normal subjects (NS), 31 patients with aMCI, 70 patients with mild AD (AD-mild), 28 patients with DLB, 31 patients with PD and 36 patients with iRBD. The OSIT-J consists of 12 types of odor sticks. The subjects were asked to select an odor from a list of 4 odors that were rubbed on the medicine wraping paper for each odor stick. The maximum score was 12. Results: The mean odor identification (OI) score decreased in the order of aMCI, iRBD, AD-mild, PD and DLB (NS: aMCI, P
Acta medica Nagasakiensia, 65(2), pp.29-36; 2022