A COMPARISON OF THE EFFICACY OF DOXYCYCLINE (DOTC) AND ROLITETRACYCLINE (ROLI-TC) IN URINARY TRACT INFECTION WITH THE USE OF INTRAVENOUS ADMINISTRATION

In order to evaluate the efficacy and safety of new antibiotics, Doxycycline (DOT C) and Rolitetracycline (Roli-TC) with the use of intravenous administration in urinary tract infections, a well-controlled open study was carried out, and the following results were obtained. 1) Any significant difference between the efficancy of these two drugs in urinary tract infections could not be found with the statistical analysis using x2-test, direct probability, multiple regression analysis, and discriminant analysis with calculated sample score by quantification theory. 2) A simple mathematical values calculated on the efficacy of these drugs with the incidence of the significant or efficient therapeutic results were 56.5% in DOTC-group and 42.0% in Roli-TC-group. And the incidence of the side-effects, including anorexia, flare, slight increase of serum GOT and GPT, and 1 case of allergic hives, and 3 cases of paralysed feeling of the tongue, were 3.2% in DOTC-group and 7.8% in Roli-TC-group. Four cases in Roli-TC-group dropped out due to lack of post-administrative clinical data, including one case of exanthema as the side-effect.