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Expression and Distribution of Cyclooxygenase-2 in Human Ovary during Follicular Development
- Source :
- Osaka City Medical Journal. 49(1):39-47
- Publication Year :
- 2003
- Publisher :
- OSAKA CITY MEDICAL CENTER, 2003.
-
Abstract
- Prostaglandins play important roles for oocyte maturation and follicular rupture. Cyclooxygenase-2 (COX-2), an inducible isoform of a prostaglandin metabolic enzyme, is essential for the timed production of prostaglandins in the ovary. The aim of the present study is to examine expression and distribution of COX-2 in human ovarian follicles at each of the maturation stages. Immunohistochemical staining shows that COX-2 is expressed in the granulosa cell layer of secondary and developing follicles, but is not detected in primary and Graafian follicles....
- Subjects :
- Ovulation
IVF-ET
COX-2
Follicular development
Subjects
Details
- Language :
- English
- ISSN :
- 00306096
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Osaka City Medical Journal
- Accession number :
- edsair.jairo.........73152139e0a3563329f25a3da4e88d42