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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations
- Source :
- Antimicrobial Agents and Chemotherapy. 67(4):e012432
- Publication Year :
- 2023
- Publisher :
- American Society for Microbiology, 2023.
-
Abstract
- Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro.<br />Antimicrobial agents and chemotherapy, 67(4), art. no. e0124322; 2023
- Subjects :
- echinocandins
gastrointestinal tract
Candida auris
yeast
antifungal resistance
FKS1
Subjects
Details
- Language :
- English
- ISSN :
- 00664804
- Volume :
- 67
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.jairo.........aec3237964e2c3458da982b296bb4fd6