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Clinical and fundamental studies on ceftriaxone (CTRX) against urinary tract infections

Authors :
NISHIO, Shoichi
YOSHIHARA, Hidetaka
Source :
泌尿器科紀要. 34(5):937-942
Publication Year :
1988
Publisher :
泌尿器科紀要刊行会, 1988.

Abstract

1)複雑性尿路感染症患者例を対象としてCTRX 1.0 gを1日1回投与した場合の効果をUTI評価基準に基づいて判定した.2)その結果, Excellent 20%, Moderate 65%, Poor 15%でoverall effectiveness rateは85%であった.3) UTI感染群別でみるとカテーテル留置例であるG-1, G-5群における効果が他の群に比して劣っていた.4)細菌学的効果は分離菌27株のうち17株(62.8%)が消失し, disk法による感受性テストではE. coli, P. aerginosa, S. epidermidisなどに対する感受性が高かった.5)腎機能障害者(血液透析患者)におけるCTRXの血中濃度の経時的変化を検討した.その結果, 投与4時間目以後plateauとなり, 長時間にわたり高い血中濃度が維持された.また, 血液透析によるCTRXの除去効果は著明なものでなく, 透析・非透析日に関係なく同一条件で投与可能と考えられた.6) CTRXの投与に由来すると思われる重篤な副作用や血液所見の異常値は認められなかった<br />Clinical efficacy of ceftriaxone (CTRX) against complicated urinary tract infections in 20 patients was examined, and the serum CTRX level was also measured in the patients with chronic renal failure (CRF). CTRX was administered at a dose of 1.0 g once a day for 5 to 10 days. The overall clinical efficacy was rated excellent in 4 cases (20%), moderate in 13 cases (65%) and poor in 3 cases (15%) with a total efficacy of 85%. Seventeen out of 27 strains (62.8%) isolated were eradicated after CTRX administration. In the patients with CRF, serum levels were very high and showed a plateau 4 hours after the injection. Furthermore, CTRX may not be removed by usual hemodialysis treatment. There were no severe side effects due to CTRX in these patients.

Subjects

Subjects :
Clinical Efficacy
CTRX
UTI
CRF
494.9

Details

Language :
Japanese
ISSN :
00181994
Volume :
34
Issue :
5
Database :
OpenAIRE
Journal :
泌尿器科紀要
Accession number :
edsair.jairo.........d4ecda76a3e61ab99ace20b25f543b95