睾丸腫瘍の化学療法に関する研究 第2編: 塩化カドニウムの睾丸腫瘍に及ぼす影響について

As the basic experiment, rats were given CdCl2 to induce testicular necrosis and the main organs were examined histologically. No noticeable abnormalitiy was evident in any organ other than testicle. Histological alteration along with distribution of radioactivity in various organs following administration of 115mCd (NO3)2 confirmed that the testicles become necrotic with minimal doses. These indicated that cadmium salt is applicable in human. Three patients with testicular tumor were treated with cadmium salt. In a case of seminoma, reduction of metastasized lesion was observed although the effect was transient No influence of treatment was seen in the second case of embryonal carcinoma. The third treated patient with embryonal carcinoma developed gross hemorrhage from the lung and retroperitoneal metastatic foci on the seventh treatment day. The patient expired one month later and autopsy revealed atrophy of the remaining testicular tissue as well as marked angionecrosis in the testicular interstitial arteries. Based on these evidences, it is supposed that cadmium salts are agent for testicular tumors.