Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass - The role of tissue injury by surgical incision

Study objectives: Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB), In this study, we examined whether tissue injury caused by chest surgical incision per se contributes to complement activation in CABG patients. Design: Prospective study. Setting: Thorax center in university hospital. Patients: Twenty-two patients undergoing CABG without CPB were prospectively divided into two groups: a small chest incision via an anterolateral thoracotomy representing a minimized tissue injury (lateral group, n = 8), and a conventional median sternotomy representing a large tissue injury (median group, n 14). Biochemical markers indicating complement activation as well as systemic inflammatory response were determined before, during, and after the operation. Measurements and results: Plasma concentrations of complement 3a increased in both the lateral and median groups right after chest incision (p