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Drug screening on 3D tumor spheroids
- Source :
- 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), 45-46, STARTPAGE=45;ENDPAGE=46;TITLE=20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
- Publication Year :
- 2016
- Publisher :
- The Chemical and Biological Microsystems Society, 2016.
-
Abstract
- We report a versatile platform for the production of spheroids of various dimensions, based on tumor cells only (mono-culture spheroids) or a combination of tumor cells and fibroblasts (co-culture spheroids). Spheroids prepared in microwells of different dimensions and with different cellular compositions are characterized in terms of size, cellular organization, and protein expression profiles. Following this, drug screening assays are conducted, either in situ in the production platform or in a separate microfluidic platform in which individual microtissues are isolated, trapped and exposed to model nanoparticle solutions under either static or dynamic conditions.
- Subjects :
- Microwell array
Drug screening
embryonic structures
3D tumor spheroids
Nanoparticles
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), 45-46, STARTPAGE=45;ENDPAGE=46;TITLE=20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
- Accession number :
- edsair.narcis........3d3700119b42d355b0a04c4d8886c375