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Clotting and fibrinolytic disturbance during lung transplantation: Effect of low-dose aprotinin

Authors :
Gu, YJ
deHaan, J
Brenken, UPM
Prop, J
vanOeveren, W
Source :
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 112(3), 599-606. MOSBY-ELSEVIER
Publication Year :
1996

Abstract

Patients undergoing lung transplantation are often confronted,vith a bleeding problem that may be due in part to the use of cardiopulmonary bypass and its activation of blood clotting and fibrinolysis. Objective: We performed a prospective study to determine whether and to what extent the clotting and fibrinolytic systems are being activated and whether low-dose aprotinin is effective in inhibiting blood activation during lung transplantation. Methods: Thirty lung transplantations performed on 29 patients were divided into a group with cardiopulmonary bypass alone (n = 12), a group with cardiopulmonary bypass and 2 x 10(6) KIL aprotinin administered at the beginning of bypass in the pump prime (n = 12), and a group without cardiopulmonary bypass (n = 6), Serial blood samples were taken from the recipient before anesthesia, seven times during the operation, and 4 and 24 hours thereafter, Results: Results show that in the group having cardiopulmonary bypass alone, the concentration of the clotting marker thrombin/antithrombin III complex increased significantly during the early phase of the operation (p

Details

Language :
English
ISSN :
00225223
Database :
OpenAIRE
Journal :
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 112(3), 599-606. MOSBY-ELSEVIER
Accession number :
edsair.narcis........54cbaaffb00c65b17b6e71ab3c4d2677