Back to Search
Start Over
Population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome
- Source :
- British Journal of Clinical Pharmacology, 80(2), 242. NLM (Medline)
- Publication Year :
- 2015
-
Abstract
- Aim The aim was to investigate the population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome. Methods Non-linear mixed effects modelling was performed on samples collected during a randomized controlled trial. Samples were collected from children who were receiving 2.5mg kg-1 levamisole (or placebo) orally once every other day. One hundred and thirty-six plasma samples were collected from 38 children from India and Europe and included in the analysis. A one compartment model described the data well. Results The apparent clearance rate (CL/F) and distribution volume (V/F) were 44l h-1 70kg-1 and 236l 70kg-1, respectively; estimated interindividual variability was 32-42%. In addition to allometric scaling of CL/F and V/F to body weight, we identified a significant proportional effect of age on CL/F (-10.1% per year). The pharmacokinetics parameters were not affected by gender, tablet strength or study centre. The median (interquartile range) maximum plasma concentration of levamisole was 438.3 (316.5-621.8) ng ml-1, and the median area under the concentration-time curve was 2847 (2267-3761) ng ml-1 h. Median tmax and t1/2; values were 1.65 (1.32-2.0) h and 2.60 (2.06-3.65) h, respectively. Conclusions Here, we present the first pharmacokinetic data regarding levamisole in children with steroid-sensitive nephrotic syndrome. The pharmacokinetic profile of levamisole in children was similar to findings reported in adults, although the elimination rate was slightly higher in children.
- Subjects :
- area under the curve
volume of distribution
drug clearance
body weight
remission
male
population pharmacokinetics
controlled study
human
randomized controlled trial (topic)
2005-005745-18
relapse
child
clinical article
elimination half-life
levamisole
drug absorption
nephrotic syndrome
maximum plasma concentration
drug half life
article
prednisolone
steroid sensitive nephrotic syndrome
compartment model
time to maximum plasma concentration
female
priority journal
adolescent
prednisone
multicenter study (topic)
plasma concentration-time curve
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology, 80(2), 242. NLM (Medline)
- Accession number :
- edsair.narcis........68d9a39c611e6ff81d6828ac5ce79071