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Haemolytic anaemia as a first sign of Wilson's disease

Authors :
Balkema, S.
Hamaker, M. E.
Visser, H. P. J.
Heine, G. D. N.
Beuers, U.
Other departments
AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Gastroenterology and Hepatology
Source :
Netherlands journal of medicine, 66(8), 344-347. Van Zuiden Communications BV
Publication Year :
2008

Abstract

A 19-year-old female presented with haemolytic anaemia and subsequently developed liver failure. This raised suspicion of Wilson's disease, which was confirmed by Kayser-Fleischer rings, a low ceruloplasmin level, raised 24-hour urinary copper excretion and two mutations in the 'Wilson gene'. She was successfully treated with D-penicillamine and zinc. In young patients with unexplained haemolysis, liver dysfunction or neuro-psychiatric symptoms, Wilson's disease should be considered

Details

Language :
English
ISSN :
03002977
Database :
OpenAIRE
Journal :
Netherlands journal of medicine, 66(8), 344-347. Van Zuiden Communications BV
Accession number :
edsair.narcis........a35dbe08508d272b2aad06dc766e2691