PHARMACOKINETICS OF CYCLOSPORINE-A AFTER INTRAVENOUS AND ORAL-ADMINISTRATION IN LIVER-TRANSPLANT PATIENTS MEASURED WITH HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Cyclosporine A (CsA) bioavailability after i.v. and oral administration was studied in six stable liver transplant patients with open and clamped bile drain. CsA levels were determined by the high-performance liquid chromatography method (HPLC). External bile drainage decreased CsA absorption considerably. Clamping the bile drain resulted in higher and earlier peak CsA levels. Clamping the bile drain increased the bioavailability (9.6% vs. 7%, p