Indirect identification of transfer function specific to cell line dynamics

Glioblastoma is the most common highest-grade and lethal type of brain tumor, causing a high rate of death each year worldwide. Given the resistance of this tumor to standard surgery, radiation and chemotherapy, the consistent efforts to comprehensively profile glioblastomas using latest technologies are addressing this need. In line with this idea, this paper focuses to enhancing an understanding of the potentially useful corrélations between medicine field and electrical engineering, as parts of our knowledge about life, Nature and Universe. Analysis of variables specific to a biological system by type of tumor cell populations can be made by analogy with the electric structure of passive quadrupole type. The transfer function is determined directly through a complex electronic structures encompassing a RC (resistor, capacitance) quadrupole + operational amplifier OA. By evaluating in vitro of the cell line GB9B, derived from glioblastoma, (GB), and based on the analysis of residues is determined indirectly, and validates the transfer function. Mathematical model of transfer function type enables to simulate numerical 3D of the expression of the output quantity. The findings of this work supports the belief in the power of science, demonstrating the strong links between the research in medicine field and the electrical engineering outcomes.