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[Untitled]

Authors :
Hertog, J. den
Spaink, H.P.
Wezel, G.P. van
Martin, N.I.
Claessen, D.
Hamoen, L.W.
Rooijakkers, S.H.M.
Leiden University
Publication Year :
2021

Abstract

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial mechanism of action (MoA) identification. With this strategy, we have discovered several interesting antimicrobial agents and have demonstrated the detailed antimicrobial property of two of them, berkchaetoazaphilone B (BAB) and harzianic acid (HA).

Details

Database :
OpenAIRE
Accession number :
edsair.od.......202..cee3d2b9bc59c7c7dc2d140da4a1caf3