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Composite selection signals: application in purebred dogs

Composite selection signals: application in purebred dogs

Authors :
Hsu, Wei Tse
Publication Year :
2022
Publisher :
The University of Sydney, 2022.

Abstract

Composite selection signals (CSS) have demonstrated that the locus or interesting regions can be localised in multi-breed populations. Here, we investigated the application of CSS to canine SNP data to assess previously known signatures or identify novel regions from various purebred dogs breed comparisons. Chapter 2 was to apply CSS to a publicly available dataset to construct a high-resolution positive selection map for three complex traits in Asian dogs. Estimates of CSS provide clear evidence that any regions of significant SNPs captured is highly likely to contain a strong candidate genes or variants of positive selection via the breed grouping strategy and methodology. Next, Chapter 3 was to identify genomic region under positive selection in Bullmastiffs. Most notable were genomic regions, candidate genes and related pathways associated with the distinct morphology of the breed. Chapter 4 was to identify selection signatures in the Mastiff-like breeds that correspond to lymphoma susceptibility. The combination of phenotypes based on breed-specific disease risk profiles with CSS has been successful in defining genomic regions that may contribute to lymphoma risk in Mastiff-like dog breeds. Finally, Chapter 5 presents of analyses CNV and selection signatures in a population of Australian Border Collies, including a sub-group of lymphoma cases. The use of the CSS approach for the analysis of lymphoma susceptibility based on positively selected regions in Border Collies produced a range of novel gene candidates that provide a basis for investigation of the genomic landscape of canine lymphoma in future studies. Overall, the methodology used in this study provides a detailed investigation about the core traits influenced by the strong selection events in canine breeds and presents novel insights about the hotspots of positive selection in the canine genome.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od.......293..413c42e694e6877addbe8da31651c2ce