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Lower Pretreatment Gut Integrity Is Independently Associated With Fat Gain on Antiretroviral Therapy
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 8
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- BACKGROUND:Fat accumulation and insulin resistance remain a threat to the success of antiretroviral therapy (ART). The role of gut dysfunction in metabolic complications associated with ART initiation is unclear. METHODS:Human immunodeficiency virus (HIV)-infected ART-naive participants were randomized to tenofovir disoproxil fumarate/emtricitabine plus atazanavir/ritonavir, darunavir/ritonavir, or raltegravir (RAL). Changes in the gut integrity markers zonulin, lipopolysaccharide-binding protein (LBP), and intestinal fatty acid and ileal bile acid binding proteins (I-FABP and I-BABP) were assessed over 96 weeks. Wilcoxon rank-sum tests were used to compare changes between groups and linear regression models to quantify associations between gut markers, insulin resistance, body mass index (BMI), and visceral, subcutaneous, and total adipose tissue (VAT, SAT, and TAT). RESULTS:: 90% were male and 48% were White non-Hispanic. The median age was 36 years, HIV-1 ribonucleic acid was 4.56 log10 copies/mL, and CD4 count was 338 cells/µL. An overall 1.7-fold increase in I-FABP was observed throughout 96 weeks, with no difference between arms. Zonulin levels increased with RAL compared to protease inhibitor-based regimens (week 96, P = .02); minimal changes in I-BABP or LBP levels were observed. Higher baseline I-FABP levels were associated with increases in VAT, TAT, and BMI (16%, 9%, and 2.5%, respectively; P < .04) over 96 weeks. CONCLUSIONS:While ART induces changes in the markers of gut barrier dysfunction, the extent to which they improve or worsen the gut barrier function remains unclear. Nevertheless, markers of gut barrier dysfunction in ART-naive individuals predict increases in total and visceral abdominal fat with treatment initiation.
- Subjects :
- Adult
Male
body composition
microbial translocation
Anti-HIV Agents
Prevention
Evaluation of treatments and therapeutic interventions
HIV Infections
Middle Aged
Biological Sciences
Medical and Health Sciences
Microbiology
Oral and gastrointestinal
Gastrointestinal Microbiome
Infectious Diseases
Good Health and Well Being
Clinical Research
6.1 Pharmaceuticals
Humans
HIV/AIDS
Female
Infection
Biomarkers
gut integrity
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 8
- Accession number :
- edsair.od.......325..04e959b9e1cf9b861fe78aa7136c793f