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Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
- Source :
- Science (New York, N.Y.), vol 347, iss 6217
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- Lysosomes are crucial cellular organelles for human health that function in digestion and recycling of extracellular and intracellular macromolecules. We describe a signaling role for lysosomes that affects aging. In the worm Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization of a lysosomal lipid chaperone LBP-8, which promoted longevity by activating the nuclear hormone receptors NHR-49 and NHR-80. We used high-throughput metabolomic analysis to identify several lipids in which abundance was increased in worms constitutively overexpressing LIPL-4. Among them, oleoylethanolamide directly bound to LBP-8 and NHR-80 proteins, activated transcription of target genes of NHR-49 and NHR-80, and promoted longevity in C. elegans. These findings reveal a lysosome-to-nucleus signaling pathway that promotes longevity and suggest a function of lysosomes as signaling organelles in metazoans.
- Subjects :
- Cell Nucleus
Aging
Cytoplasmic and Nuclear
General Science & Technology
1.1 Normal biological development and functioning
Longevity
Lipase
Lipid Metabolism
Active Transport
Underpinning research
Receptors
Genetics
Animals
Generic health relevance
Lysosomes
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Molecular Chaperones
Signal Transduction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.), vol 347, iss 6217
- Accession number :
- edsair.od.......325..24ef6327c260c80bd9907767eb09482b