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The neuroinflammatory marker sTNFR2 relates to worse cognition and tau in women across the Alzheimer's disease spectrum
- Source :
- Alzheimer's & dementia (Amsterdam, Netherlands), vol 14, iss 1
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- IntroductionDespite women showing greater Alzheimer's disease (AD) prevalence, tau burden, and immune/neuroinflammatory response, whether neuroinflammation impacts cognition differently in women versus men and the biological basis of this impact remain unknown. We examined sex differences in how cerebrospinal fluid (CSF) neuroinflammation relates to cognition across the aging-mild cognitive impairment (MCI)-AD continuum and the mediating role of phosphorylated tau (p-tau) versus other AD biomarkers.MethodsParticipants included 284 individuals from the Alzheimer's Disease Neuroimaging Initiative study. CSF neuroinflammatory markers included interleukin-6, tumor necrosis factor α, soluble tumor necrosis factor receptor 2 (sTNFR2), and chitinase-3-like protein 1. AD biomarkers were CSF p-tau181 and amyloid beta1-42 levels and magnetic resonance imaging measures of hippocampal and white matter hyperintensity volumes.ResultsWe found a sex-by-sTNFR2 interaction on Mini-Mental State Examination and Clinical Dementia Rating-Sum of Boxes. Higher levels of sTNFR2 related to poorer cognition in women only. Among biomarkers, only p-tau181 eliminated the female-specific relationships between neuroinflammation and cognition.DiscussionWomen may be more susceptible than men to the adverse effects of sTNFR2 on cognition with a potential etiological link with tau to these effects.
- Subjects :
- sex differences
Aging
aging
Alzheimer's Disease Neuroimaging Initiative
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Alzheimer's disease
phosphorylated tau
Neurodegenerative
Alzheimer's Disease
neuroinflammation
Brain Disorders
Good Health and Well Being
Behavioral and Social Science
Neurological
Acquired Cognitive Impairment
Genetics
magnetic resonance imaging
2.1 Biological and endogenous factors
Dementia
Aetiology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & dementia (Amsterdam, Netherlands), vol 14, iss 1
- Accession number :
- edsair.od.......325..26799cbacf87440e6c4686e1f6a3fcf8