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Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders
- Source :
- Journal of acquired immune deficiency syndromes (1999), vol 74, iss 4
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Monocytes play a vital role in HIV-associated neurocognitive disorder (HAND), postulated to transport HIV into the brain and secrete pro-inflammatory cytokines. We analyzed cytokines released by cultured peripheral blood mononuclear cells enriched with the CD14 marker isolated from HIV-infected individuals with HAND and normal cognition (NC) in combination antiretroviral therapy naive and after 1 year on treatment. Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline (P = 0.002 and P < 0.0001). These cytokines remained higher in HAND patients 1 year after combination antiretroviral therapy and were significant when NC patients who were initially HAND were excluded (P = 0.012 and P = 0.002). Both correlated with baseline CD14 peripheral blood mononuclear cell HIV DNA levels supporting the role of HIV DNA reservoir size and monocyte cytokines in HAND persistence.
- Subjects :
- AIDS Dementia Complex
Gene Expression Profiling
Mononuclear
Clinical Sciences
Lipopolysaccharide Receptors
Neurosciences
Evaluation of treatments and therapeutic interventions
HIV Infections
Viral Load
Monocytes
Brain Disorders
SEARCH 011 Study Group
Mental Health
Infectious Diseases
Clinical Research
6.1 Pharmaceuticals
Virology
Leukocytes
Genetics
Public Health and Health Services
Humans
Cytokines
HIV/AIDS
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes (1999), vol 74, iss 4
- Accession number :
- edsair.od.......325..89e6bf2ea936c9d769a4d427d5aff7c5