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Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV
- Source :
- Journal of acquired immune deficiency syndromes (1999), vol 78, iss 1
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- BackgroundThere is persistent confusion as to whether abacavir (ABC) increases the risk of myocardial infarction (MI), and whether such risk differs by type 1 (T1MI) or 2 (T2MI) MI in adults with HIV.MethodsIncident MIs in North American Cohort Collaboration on Research and Design participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude hazard ratio (HR) and adjusted hazard ratio (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately. A sensitivity analysis evaluated whether Framingham risk score (FRS) modified the effect of ABC on MI occurrence.ResultsEight thousand two hundred sixty-five adults who initiated antiretroviral therapy contributed 29,077 person-years and 123 MI events (65 T1MI and 58 T2MI). Median follow-up time was 2.9 (interquartile range 1.4-5.1) years. ABC initiators were more likely to have a history of injection drug use, hepatitis C virus infection, hypertension, diabetes, impaired kidney function, hyperlipidemia, low (
- Subjects :
- Adult
Male
Aging
Clinical Sciences
Myocardial Infarction
HIV Infections
Cardiovascular
Risk Assessment
Cohort Studies
Risk Factors
Virology
Humans
causal inference
Heart Disease - Coronary Heart Disease
Aged
North American AIDS Cohort Collaboration on Research and Design of IeDEA
Prevention
abacavir
HIV
Middle Aged
Dideoxynucleosides
CD4 Lymphocyte Count
Heart Disease
Good Health and Well Being
Antirheumatic Agents
North America
Public Health and Health Services
HIV/AIDS
Female
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes (1999), vol 78, iss 1
- Accession number :
- edsair.od.......325..a6cd2214a34d358368302b4908c710d8