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Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV

Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV

Authors :
Elion, Richard A
Althoff, Keri N
Zhang, Jinbing
Moore, Richard D
Gange, Stephen J
Kitahata, Mari M
Crane, Heidi M
Drozd, Daniel R
Stein, James H
Klein, Marina B
Eron, Joseph J
Silverberg, Michael J
Mathews, William C
Justice, Amy C
Sterling, Timothy R
Rabkin, Charles S
Mayor, Angel M
Klein, Daniel B
Horberg, Michael A
Bosch, Ronald J
Eyawo, Oghenowede
Palella, Frank J
North American AIDS Cohort Collaboration on Research and Design of IeDEA
Source :
Journal of acquired immune deficiency syndromes (1999), vol 78, iss 1
Publication Year :
2018
Publisher :
eScholarship, University of California, 2018.

Abstract

BackgroundThere is persistent confusion as to whether abacavir (ABC) increases the risk of myocardial infarction (MI), and whether such risk differs by type 1 (T1MI) or 2 (T2MI) MI in adults with HIV.MethodsIncident MIs in North American Cohort Collaboration on Research and Design participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude hazard ratio (HR) and adjusted hazard ratio (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately. A sensitivity analysis evaluated whether Framingham risk score (FRS) modified the effect of ABC on MI occurrence.ResultsEight thousand two hundred sixty-five adults who initiated antiretroviral therapy contributed 29,077 person-years and 123 MI events (65 T1MI and 58 T2MI). Median follow-up time was 2.9 (interquartile range 1.4-5.1) years. ABC initiators were more likely to have a history of injection drug use, hepatitis C virus infection, hypertension, diabetes, impaired kidney function, hyperlipidemia, low (

Details

Database :
OpenAIRE
Journal :
Journal of acquired immune deficiency syndromes (1999), vol 78, iss 1
Accession number :
edsair.od.......325..a6cd2214a34d358368302b4908c710d8