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Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
- Source :
- Journal of Alzheimer's disease : JAD, vol 73, iss 1
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- BackgroundCardiovascular disease is linked to cognitive decline and disorders (e.g., dementia). The evidence is based largely on older non-Latino White cohorts.ObjectiveExamine the association between global vascular risk and cognitive function among Hispanics/Latinos in the United States.MethodsWe used data from a large sample of stroke- and cardiovascular disease-free, middle-aged and older Hispanics/Latinos with diverse backgrounds (n=7,650) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We compared associations between two measures of cardiovascular risk (CVR), the Framingham Cardiovascular Risk Score (FCRS) and the multiethnic Global Vascular Risk Score (GVRS), and cognitive performance using measures of global and domain specific cognitive function, and tested for modification by sex and age.ResultsHigher FCRS and GVRS were associated with lower global cognition and higher probability of low mental status, after covariates adjustment. Both CVR indices were associated with lower performances in learning and memory, verbal fluency, and psychomotor speed. Higher GVRS presented stronger associations with lower cognitive function compared to the FCRS. Women and younger age (45-64 years) exhibited more pronounced associations between higher CVR and worse cognition, particularly so with the GVRS.DiscussionCVR is also a risk for compromised cognitive function and evident in middle-age among Hispanics/Latinos. The multiethnic GVRS, tailored to specific risks based on racial/ethnic background, is feasible to use in primary care settings and can provide important insight on cognitive risk. Even modest shifts in population toward cardiovascular health in the high-risk Hispanic/Latino population can have important positive impacts on healthy cognitive aging.
- Subjects :
- Male
cognition
Aging
Hispanics/Latinos
Clinical Sciences
neuropsychology
Neuropsychological Tests
Cardiovascular
Basic Behavioral and Social Science
Cohort Studies
Sex Factors
Residence Characteristics
Clinical Research
neuroepidemiology
Behavioral and Social Science
80 and over
Humans
Cognitive Dysfunction
Prospective Studies
Aged
Neurology & Neurosurgery
Prevention
Age Factors
Neurosciences
Hispanic or Latino
Middle Aged
Cardiovascular risk
United States
Brain Disorders
Mental Health
Good Health and Well Being
Cardiovascular Diseases
Heart Disease Risk Factors
Female
Cognitive Sciences
Cognition Disorders
HCHS/SOL
Psychomotor Performance
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD, vol 73, iss 1
- Accession number :
- edsair.od.......325..af95e492973965cc3a2fad621be450b7