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Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies
- Source :
- Cancer, vol 122, iss 6
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- BackgroundThe current study was conducted to evaluate the performance of magnetic resonance (MR)-ultrasound-guided fusion biopsy in diagnosing clinically significant prostate cancer (csCaP).MethodsA total of 1042 men underwent multiparametric MR imaging (mpMRI) and fusion biopsy consecutively in a prospective trial (2009-2014). An expert reader graded mpMRI regions of interest (ROIs) as 1 to 5 using published protocols. The fusion biopsy device was used to obtain targeted cores from ROIs (when present) followed by a fusion image-guided, 12-core systematic biopsy in all men, even if no suspicious ROI was noted. The primary endpoint of the study was the detection of csCaP (ie, Gleason score ≥ 7).ResultsAmong 825 men with ≥ 1 suspicious ROI of ≥ grade 3, 289 (35%) were found to have csCaP. Powerful predictors of csCaP were ROI grade (grade 5 vs grade 3: odds ratio, 6.5 [P
- Subjects :
- Male
Image-Guided Biopsy
Urologic Diseases
diagnostic imaging
Biopsy
Oncology and Carcinogenesis
Multimodal Imaging
Predictive Value of Tests
Clinical Research
Needle
Odds Ratio
Humans
magnetic resonance imaging
Prospective Studies
Oncology & Carcinogenesis
Ultrasonography
Aged
Cancer
screening and diagnosis
Tumor
Interventional
cancer staging
Prevention
Prostate Cancer
Prostatic Neoplasms
Prostate-Specific Antigen
Middle Aged
Detection
Public Health and Health Services
Biomedical Imaging
Biomarkers
4.2 Evaluation of markers and technologies
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cancer, vol 122, iss 6
- Accession number :
- edsair.od.......325..ccb9639bc8792ca5665b4457ce19cdaa