Back to Search
Start Over
Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- PurposeBlood glucose is routinely measured prior to 18F-fluorodeoxyglucose (FDG) administration in positron emission tomography (PET) imaging to identify hyperglycemia that may affect image quality. In this study we explore the effects of blood glucose levels upon semi-quantitative standardized uptake value (SUV) measurements of target organs and tissues of interest and in particular address the relationship of blood glucose to FDG accumulation in the brain and liver.Methods436 FDG PET/CT consecutive studies performed for oncology staging in 229 patients (226 male) at the Ann Arbor Veterans Administration Healthcare System were reviewed. All patients had blood glucose measured (112.4±34.1mg/dL) prior to injection of 466.2±51.8MBq (12.6±1.4mCi) of FDG. SUV measurements of brain, aortic arch blood-pool, liver, and spleen were obtained at 64.5±10.2min' post-injection.ResultsWe found a negative inverse relationship of brain SUV with increasing plasma glucose, levels for both absolute and normalized (either to blood-pool or liver) values. Higher blood glucose levels had a mild effect upon liver and blood-pool SUV. By contrast, spleen SUV was independent of blood glucose, but demonstrated the greatest variability (deviation on linear regression). In contrast to other tissues, liver and spleen SUV normalized to blood-pool SUV were not dependent upon blood glucose levels.ConclusionThe effects of hyperglycemia upon FDG uptake in brain and liver, over a range of blood glucose values generally considered acceptable for clinical PET imaging, may have measurable effects on semi-quantitative image analysis.
- Subjects :
- Blood Glucose
Male
Clinical Trials and Supportive Activities
Quantitative imaging
Bioengineering
Basal Ganglia
Fluorodeoxyglucose F18
Clinical Research
Humans
Oncology & Carcinogenesis
Liver Disease
Brain
(18)F-FDG biodistribution
Pharmacology and Pharmaceutical Sciences
Middle Aged
PET
Liver
Hyperglycemia
Positron-Emission Tomography
Multivariate Analysis
Linear Models
Biomedical Imaging
Female
Digestive Diseases
PERCIST
Alzheimer’s
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.od.......325..e5764c8b53b72058fe4b02fe25453ac6