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HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women
- Source :
- Journal of gastroenterology and hepatology, vol 32, iss 4
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Background and aimWomen who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy. We used data from a population cohort study to model the impact of menstruation cessation at menopause on serum ferritin (SF) levels in female p.C282Y homozygotes, with p.C282Y/p.H63D simple or compound heterozygotes and those with neither p.C282Y nor p.H63D mutations (HFE wild types) as comparison groups.MethodsA sample of the Melbourne Collaborative Cohort Study was selected for the "HealthIron" study (n=1438) including all HFE p.C282Y homozygotes plus a random sample stratified by HFE-genotype (p.C282Y and p.H63D). The relationship between the natural logarithm of SF and time since menopause was examined using linear mixed models incorporating spline smoothing.ResultsFor p.C282Y homozygotes, SF increased by a factor of 3.6 (95% CI (1.8, 7.0), P&nbsp
- Subjects :
- Adult
Aging
Genotype
Clinical Sciences
menopause
HealthIron Study Investigators
Cohort Studies
Genetics
Humans
2.1 Biological and endogenous factors
Genetic Predisposition to Disease
Aetiology
Hemochromatosis Protein
Aged
Gastroenterology & Hepatology
Contraception/Reproduction
Liver Disease
Prevention
Homozygote
Australia
Hematology
Middle Aged
HFE p.C282Y homozygosity
HFE p
hereditary hemochromatosis
women's health
iron overload-related disease
iron accumulation
Mutation
Ferritins
C282Y homozygosity
Female
Hemochromatosis
Digestive Diseases
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of gastroenterology and hepatology, vol 32, iss 4
- Accession number :
- edsair.od.......325..ffd0a32c8f53a83ebe5a0dc70950ebef