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Asymmetric Synthesis of Diastereomerically and Enantiomerically Pure 3-Substituted (2R,3S)-Serine Methyl Esters
- Publication Year :
- 1991
-
Abstract
- The titanium derivative 2 of the bislactim ether 1 of cyclo(-LVal-Gly-) reacts with aldehydes and ketones 3 highly diastereoselectively to give the syn-addition products 4. Upon hydrolysis with diluted trifluoroacetic acid the compounds 4 yield besides methyl L-valinate the (2R,BS)-threo-serinme ethyl esters 5.
- Subjects :
- methyl esters
Bislactim ether method
3-substituted
ddc:540
Serine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od.......715..8d9245170070b6a34535e93757f48b03