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Ternary Coordination Compounds of Copper(II) with Glycine and 2,2'-bipyridine: Synthesis, Structural Characterization, Magnetic and Biological Properties
- Source :
- Croatica Chemica Acta, Volume 95, Issue 4 (online first)
- Publication Year :
- 2022
- Publisher :
- Croatian Chemical Society, 2022.
-
Abstract
- Three new coordination compounds of copper(II) with glycine (HGly) and 2,2'-bipyridine (bipy) were synthesized by solution-based and mechanochemical methods: [Cu(Gly)(H2O)(bipy)][Cu(Gly)(SO4)(bipy)]·6H2O (1a·6H2O), [Cu(Gly)(H2O)(bipy)]2SO4 (1b), [Cu(Gly)(H2O) (bipy)]2SO4·H2O (1b·H2O). The amount of water in the reaction mixture influenced the product of crystallization. All compounds were characterized by X-ray diffraction methods and form 1D infinite chains or 2D sheets of complex ions connected by π-interactions. Compounds 1a·6H2O and 1b were characterized by X-band electron spin resonance (ESR) spectroscopy and the values of g-tensors for Cu(II) ions were determined. Compounds 1a·6H2O and 1b showed pronounced antiproliferative activity toward a panel of six human cell lines. The most impared was HepG2 cell line at 10−5 mol dm−3 concentration (74.5 % reduction of cell growth) followed by moderate activity toward KATO III, Caco-2, MDA-MB-231, PANC-1 and MRC-5 cells at 10−4 mol dm−3 concentration of compounds 1a·6H2O and 1b. Generally, both compounds express similar antiproliferative effect on evaluated cells.
Details
- Language :
- English
- ISSN :
- 1334417X and 00111643
- Volume :
- 95
- Issue :
- 4 (online first)
- Database :
- OpenAIRE
- Journal :
- Croatica Chemica Acta
- Accession number :
- edsair.od.......951..39731a52ff233ba335a4f9cde92eed9e