Gold and Silver Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium-ring oxazepine core. A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. ispartof: European Journal of Organic Chemistry vol:19 issue:19 pages:4190-4197 status: published