Efficacy and tolerability of gabapentin (GBP) versus valproato (VPA) as add-on therapy to neuroleptics in the treatment of acute maniac symptoms

The published reports yelded promising results, but the interpretation of the therapeutic role of GBP in mania was difficult because the drug was already associated to a wide range of other agents, whose dose was not manteined uncharged during the study. The objective of our study was to assess the efficacy and safety of GBP versus VPA in adjunct to a fixed dose of neuroleptics (NL) in patients hospetalized because of an evidence of acute manic synptoms.