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Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium
- Publication Year :
- 2006
-
Abstract
- A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon. The aim of this study was the preparation of dry-coated tablets designed for colonic release of the model drug Diclofenac sodium (DS). The system consists of a drug-pectine (PC) mixture as the core and hydroxypropylmethylcellulose (HPMC) alone or mixed in different ratios with poly(ε-caprolactone) (CL) as the coat layer.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od......1389..d27154e249e51ec7e6fdef4a708b17a2