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Environnement, asthme sévère, allergie : EGEA
- Source :
- Revue des Maladies Respiratoires, Revue des Maladies Respiratoires, Elsevier Masson, 2007, 24 (5), pp.599-608
- Publication Year :
- 2007
- Publisher :
- HAL CCSD, 2007.
-
Abstract
- International audience; INTRODUCTION: EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article. METHODS AND RESULTS: The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy (eosinophils, IgE and atopy) and hormonal dependent events in women (premenstrual asthma, menopause and oral contraceptive use) have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis. CONCLUSIONS: New hypothesis will be tested in the near future from the second stage of this survey.
- Subjects :
- MESH: Premenstrual Syndrome
MESH: Smoking
MESH: Asthma
MESH: Menopause
MESH: Hypersensitivity
asthme sévère
allergie
MESH: Phenotype
MESH: Body Mass Index
MESH: Eosinophils
MESH: Risk Factors
MESH: Child
MESH: Environment
MESH: Age Factors
MESH: Epidemiologic Studies
MESH: Humans
MESH: Immunoglobulin E
MESH: Biological Markers
MESH: Bronchial Hyperreactivity
MESH: Adult
MESH: Case-Control Studies
MESH: Male
respiratory tract diseases
Environnement
asthme
MESH: France
MESH: Menarche
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Hypersensitivity, Immediate
MESH: Contraceptives, Oral
MESH: Female
Subjects
Details
- Language :
- French
- ISSN :
- 07618425 and 17762588
- Database :
- OpenAIRE
- Journal :
- Revue des Maladies Respiratoires, Revue des Maladies Respiratoires, Elsevier Masson, 2007, 24 (5), pp.599-608
- Accession number :
- edsair.od......1398..e3d633b81217732eff1f58de55ff46b3