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Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

Authors :
Tanabe, Shihori
O'Brien, Jason
Tollefsen, Knut Erik
Kim, Young Jun
Chauhan, Vinita
Yauk, Carole
Huliganga, Elizabeth
Rudel, Ruthann
Kay, Jennifer
Helm, Jessica
Beaton, Danielle
Filipovska, Julija
Sovadinova, Iva
Garcia-Reyero, Natalia
Mally, Angela
Poulsen, Sarah Søs
Delrue, Nathalie
Fritsche, Ellen
Luettich, Karsta
La Rocca, Cinzia
Yepiskoposyan, Hasmik
Klose, Jördis
Danielsen, Pernille Høgh
Esterhuizen, Maranda
Jacobsen, Nicklas Raun
Vogel, Ulla
Gant, Timothy
Choi, Ian
FitzGerald, Rex
Ecosystems and Environment Research Programme
Helsinki Institute of Sustainability Science (HELSUS)
Publication Year :
2022

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively referred to as reactive oxygen and nitrogen species (RONS), has recently become highly relevant in a number of adverse outcome pathways (AOPs) that capture, organize, evaluate and portray causal relationships pertinent to adversity or disease progression. RONS can potentially act as a key event (KE) in the cascade of responses leading to an adverse outcome (AO) within such AOPs, but are also known to modulate responses of events along the AOP continuum without being an AOP event itself. A substantial discussion has therefore been undertaken in a series of workshops named “Mystery or ROS” to elucidate the role of RONS in disease and adverse effects associated with exposure to stressors such as nanoparticles, chemical, and ionizing and non-ionizing radiation. This review introduces the background for RONS production, reflects on the direct and indirect effects of RONS, addresses the diversity of terminology used in different fields of research, and provides guidance for developing a harmonized approach for defining a common event terminology within the AOP developer community.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......1593..30ef966556f1a5bdaab03bf7e72b0b7e