Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Authors :: Jakszyn, P. Bingham, S. Pera, G. Agudo, A. Luben, R. Welch, A. Boeing, H. del Giudice, G. Palli, D. Saieva, C. Krogh, V. Sacerdote, C. Tumino, R. Panico, S. Berglund, G. Simán, H. Hallmans, G. Sanchez, M.J. Larrañaga, N. Barricarte, A. Chirlaque, M.D. Quirós, J.R. Key, T.J. Allen, N. Lund, E. Carneiro, F. Linseisen, J. Nagel, G. Overvad, K. Tjonneland, A. Olsen, A. Bueno-de-Mesquita, H.B. Ocké, M.O. Peeters, P.H.M. Numans, M.E. Clavel-Chapelon, F. Trichopoulou, A. Fenger, C. Stenling, R. Ferrari, P. Jenab, M. Norat, T. Riboli, E. Gonzalez, C.A.
Publication Year :: 2006
Abstract: The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

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