The Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis

BackgroundAround 5%-7% of breast cancer cases are diagnosed in women younger than 40, making it the leading cause of female cancer in the 25- to 39-year-old age group. Unfortunately, young age at diagnosis is linked to a more aggressive tumor biology and a worse clinical outcome. The identification of the mutational landscape of breast cancer in this age group could optimize the management. MethodsWe performed NGS analysis in paraffin blocks and blood samples of 32 young patients with breast cancer [