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Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Authors :
Grote, V. A. Rohrmann, S. Nieters, A. Dossus, L. and Tjonneland, A. Halkjaer, J. Overvad, K. Fagherazzi, G. and Boutron-Ruault, M. C. Morois, S. Teucher, B. Becker, S. and Sluik, D. Boeing, H. Trichopoulou, A. Lagiou, P. and Trichopoulos, D. Palli, D. Pala, V. Tumino, R. Vineis, P. Panico, S. Rodriguez, L. Duell, E. J. Molina-Montes, E. Dorronsoro, M. Huerta, J. M. Ardanaz, E. Jeurnink, S. M. Beulens, J. W. J. Peeters, P. H. M. Sund, M. Ye, W. and Lindkvist, B. Johansen, D. Khaw, K. T. Wareham, N. and Allen, N. Crowe, F. Jenab, M. Romieu, I. Michaud, D. S. and Riboli, E. Romaguera, D. Bueno-de-Mesquita, H. B. Kaaks, R.
Publication Year :
2011

Abstract

Aims/hypothesis There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) and date of tumour diagnosis. Methods Pre-diagnostic levels of HbA(1c) and C-peptide were measured for 466 participants with pancreatic cancer and 466 individually matched controls within the European Prospective Investigation into Cancer and Nutrition. Conditional logistic regression models were used to estimate ORs for pancreatic cancer. Results Pancreatic cancer risk gradually increased with increasing pre-diagnostic HbA(1c) levels up to an OR of 2.42 (95% CI 1.33, 4.39 highest [>= 6.5%, 48 mmol/mol] vs lowest [

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......2127..cef2cf923a54505bd51f3f2cf66e048b

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