Role promyelocytárního leukemického proteinu v udržování stability genomu

Promyelocytic leukemia protein (PML) is a key component for a formation of the PML nuclear bodies (PML−NBs) in which PML forms a shell surrounding an inner core of this dynamic multiprotein komplex. PML may act as a tumor supressor or a regulator of transcription factors. PML-NBs plays a role in the genome stability maintenance by participating in DNA repair including the alternative lenghtening of telomer, regulation of the cell cycle and antivirus protection. The purpose of this section is to provide information about how PML participate in the genome stability maintenance and about possible consequences of failure of these mechanisms.