Efeitos da dislipidemia materna sobre os níveis de pressão arterial, controle cardiorrespiratório e parâmetros bioquímicos na prole de fêmeas

High blood pressure evidenced in adult rats exposed to maternal dyslipidemia may be sex dependent. In this work, we investigate the effects of dyslipidemia during pregnancy and lactation on cardiorespiratory and metabolic parameters in female offspring. Rats were divided into two groups: one received a control diet (CTL) and another received dyslipidemic diet (DLP) during pregnancy and lactation. Anthropometric and biochemical parameters were performed in the pups of these rats at 30 and 90 days of age, such as: weight and length of offspring, oral glucose tolerance (OGT), insulin tolerance (IT), total cholesterol (TC) tests, high (HDL), low (LDL) and very low density (VLDL) lipoproteins, triglycerides (TG), and malondialdehyde (MDA). In addition, respiratory parameters such as respiratory frequency (RF), tidal volume (VT), and minute ventilation (VE) were assessed by whole body plethysmography during a baseline period and after activation of hypercapnic mixture (7% CO2) respiratory chemoreceptors. At 90 days of age, blood pressure (BP) and heart rate (HR) were measured under basal conditions and after administration of potassium cyanide (KCN, 0.04%) to evaluate peripheral chemoreflex, and hexamethonium (30 mg / kg) to assess sympathetic tone. Finally, we evaluated the HR and BP variability under baseline conditions. The DLP group had low birth weight (P