Oxidative metabolism of the neutrophils in sheep treated with sodium monensin and experimentally submitted to ruminal acidosis

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:15:30Z No. of bitstreams: 1 WOS000180970400001.pdf: 443263 bytes, checksum: 131b3d0869b1192b344f4593821f4e65 (MD5) Made available in DSpace on 2014-02-26T17:15:30Z (GMT). No. of bitstreams: 1 WOS000180970400001.pdf: 443263 bytes, checksum: 131b3d0869b1192b344f4593821f4e65 (MD5) Previous issue date: 2002-10-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:42:38Z No. of bitstreams: 1 WOS000180970400001.pdf: 443263 bytes, checksum: 131b3d0869b1192b344f4593821f4e65 (MD5) Made available in DSpace on 2014-05-20T13:42:38Z (GMT). No. of bitstreams: 1 WOS000180970400001.pdf: 443263 bytes, checksum: 131b3d0869b1192b344f4593821f4e65 (MD5) Previous issue date: 2002-10-01 Ruminal acidosis is due to excessive ingestion of carbohydrates of rapid fermentation without previous adaptation of the microorganisms, causing severe metabolic disturbances to the animals. The objective of the present study was to assess the neutrophilic oxidative metabolism in sheep treated with sodium monensin in experimentally induced ruminal lactic acidosis. A total of 18 male sheep, half-bred (ideal x Merino), fistulated in the rumen, were used; nine of them received 33 mg/kg of the ionophore diet per day, for 30 days; the others were controls. The acidosis was induced by supplying 15g of sucrose/kg of body weight. The clinical evaluation and the rumen and blood samples were obtained before (0h) and at 6, 12, 24 and 48 hours post-induction. In both groups, all the animals presented clinical manifestations of ruminal lactic acidosis 6 hours after the induction. From this period on, a significant pH decrease (P